Research

       

The following list is not exhaustive, but is a snapshot to show how extensive primate research is in Australia.

Click on one of the following to jump to the relevant section:
       



Examples of research involving macaques:

Winnall WR, Lloyd SB, De Rose R, Alcantara S, Amarasena TH, Hedger MP, Girling JE, Kent SJ. Simian immunodeficiency virus infection and immune responses in the pig-tailed macaque testis. J Leuk Biol 2015

Trist HM, Tan PS, Wines BD, Ramsland PA, Orlowski E, Stubbs J, Gardiner EE, Pietersz GA, Kent SJ, Stratov I, Burton DR, Hogarth PM. Polymorphisms and Interspecies Differences of the activating and inhibitory FcγRII of Macaque nemestrina Influence the Binding of Human IgG Subclasses. J Immunol 2014;192:792-803

Gooneratne S, Alinejad-Rokny H, Ebrahimi D, Bohn PS, Wiseman RW, O'Connor DH, Davenport MP, Kent SJ. Linking pig-tailed macaque major histocompatibility complex class I haplotypes and cytotoxic T lymphocyte escape mutations in SIV infection. J Virol 2014;88:14310-25

Jegaskanda S, Amarasena T, Laurie KL, Tan H-X, Butler J, Parsons MS, Alcantara S, Petravic J, Davenport MP, Hurt A, Reading PC, Kent SJ. Standard trivalent influenza protein vaccination does not prime antibody-dependent cellular cytotoxicity (ADCC) in macaques. J Virol 2013;87:13706-18

Jegaskanda S, Job ER, Kramski M, Laurie K, Isitman G, De Rose R, Winnall WR, Stratov I, Brooks A, Reading PC, Kent SJ. Cross-reactive influenza-specific antibody-dependent cellular cytotoxicity (ADCC) antibodies in the absence of neutralizing antibodies. J Immunol 2013;190:1837-1848

Xu Y, Weatherall C, Bailey M, Alcantara S, De Rose R, Estaquier J, Wilson K, Suzuki K, Corbeil J, Cooper DA, Kent SJ, Kelleher AD, Zaunders J. SIV Infects Follicular Helper CD4 T cells in Lymphoid Tissues During Pathogenic Infection of Pigtail Macaques. J Virol 2013;87:3760-3773

De Rose R, Fernandez CS, Hedger MP, Kent SJ, Winnall WR. Characterisation of macaque testicular leukocyte populations and T-lymphocyte immunity. J Reproductive Immunology 2013;100:146-156

Fernandez CS, Jegaskanda S, Godfrey DI, Kent SJ. In-vivo stimulation of macaque NKT cells with α-Galactosylceramide. Clinical and Experimental Immunology 2013;173:480-92

Reece JC, Alcantara S, Gooneratne S, Amarasena T, Fernandez CS, Laurie K, Hurt A, O'Connor S, Harris M, Petravic J, Martyushev A, Grimm A, Davenport MP, Stambas J, De Rose R, Kent SJ. Trivalent live attenuated Influenza-SIV vaccines: efficacy and evolution of CTL escape in macaques. J Virol 2013;87:4146-60

Lim CK, Yap MMC, Kent SJ, Batten CJ, De Rose R, Heng B, Brew B, Guillemin GJ. Characterization of the Kynurenine Pathway and Quinolinic Acid Production in Simian Macrophages. International Journal of Tryptophan Res 2013; 6: 7-19.

Major LD, Partridge TS, Gardner J, Kent SJ, De Rose R, Suhrbier A, Schroder WA. Induction of SerpinB2 and Th1/Th2 modulation by SerpinB2 during lentiviral infections in vivo. Plos One 2013;8:e57343

Yu X, Fernandez CS, Alcantara S, Bailey M, De Rose R, Kelleher AD, Zaunders J, Kent SJ. Serial study of lymph node cell subsets using fine needle aspiration in pigtail macaques. J Immunol Methods 2013;394:73-83

Jegaskanda S, Reece J, De Rose R, Stambas J, Sullivan L, Brooks AG, Kent SJ, Sexton A. Comparison of Influenza and SIV specific CD8 T cell responses in macaques. Plos One 2012;7:e32431

Reece J, Petravic J, Balamurali M, Loh L, Gooneratne S, De Rose R, Kent SJ, Davenport MP. An "Escape Clock" for Estimating the Turnover of SIV DNA in Resting CD4+ T Cells. Plos Pathogens 2012;8:e1002615

Winnall WR, Sexton A, Roath S, Alcantara S, De Rose R, Kent SJ. Characterisation of Simian Immunodeficiency Virus-infected cells in pigtail macaques. Virology 2012;428:11-20

Fernandez CS, Cameron G, Godfrey I, Kent SJ. Ex-vivo alpha-Galactosylceramide activation of NKT cells in humans and macaques. J Imm Methods 2012;382:150-159

Fernandez CS, Reece JC, Saepuloh U, De Rose R, Ishkandriati D, O'Connor DH, Wiseman RW, Kent SJ. Screening and confirmatory testing of MHC class I alleles in pigtail macaques. Immunogenetics 2011;63:511-21

Reece JR, Loh L, Alcantara S, Fernandez CS, Stambas J, Sexton A, De Rose R, Petravic J, Davenport MP, Kent SJ. Timing of immune escape linked to success or failure of vaccination. Plos One 2010; 5 :e12774

Balamurali B, Petravic J, Loh L, Alcantara S, Kent SJ, Davenport MP. Does cytolysis by CD8+ T cells drive immune escape in SHIV infection? J Immunol 2010 185: 5093-5101

Center RJ, Wheatley AK, Campbell SM, Gaeguta AJ, Peut V, Alcantara S, Siebentritt C, Kent SJ, Purcell DFJ. Induction of HIV-1 subtype B and AE-specific neutralizing antibodies in mice and macaques with DNA prime and recombinant gp140 protein boost regimens. Vaccine, 2009; 27: 6605-6612.

Chong SF, Sexton A, De Rose R, Kent SJ, Zelikin AN, Caruso F. A paradigm for peptide vaccine delivery using viral epitopes encapsulated in degradable polymer hydrogel capsules. Biomaterials, 2009; 30: 5178-5186.

Sexton A, De Rose R, Reece JC, Alcantara S, Loh L, Moffat JM, Laurie K, Hurt A, Doherty PC, Turner SJ, Kent SJ, Stambas J. Evaluation of recombinant Influenza-SIV vaccines in macaques. J Virol, 2009; 83: 7619-7628.

Alcantara S, Reece JC, Amarasena T, De Rose R, Manitta J, Amin J, Kent SJ. Thrombocytopenia is strongly associated with simian AIDS in pigtail macaques. J AIDS, 2009; 51: 374-379.

Loh L, Reece JC, Fernandez CS, Alcantara S, Center R, Howard J, Purcell DFJ, Balamurali M, Petravic J, Davenport MP, Kent SJ. Complexity of the inoculum determines the rate of reversion of SIV Gag CD8 T cell mutant virus and outcome of infection. PloS Pathogens, 2009;5(4): e1000378.

Fernandez CS, Chan AC, Kyparissoudis K, De Rose R, Godfrey DI, Kent SJ. Peripheral NKT cells in SIV-infected macaques. Journal of Virology, 2009; 83: 1617-1624.

De Rose R, Mason RD, Loh L, Peut V, Smith MZ, Fernandez CS, Alcantara S, Amarasena T, Reece J, Seddiki N, Kelleher AD, Zaunders J, Kent SJ. Safety, immunogenicity and efficacy of peptide-pulsed cellular immunotherapy in macaques. Journal of Medical Primatology, 2008; 37 (Supp 2): 69-78.

Mason RD, De Rose R, Seddiki N, Kelleher AD, Kent SJ. Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques. Virology, 2008; 381: 11-15.

Rollman E, Mason RD, Lin J, Brooks AG, Kent SJ. Protection afforded by live attenuated SIV is associated with rapid killing kinetics of CTLs. Journal of Medical Primatology, 2008; 37 (Supp 2): 24-32.

De Rose R, Fernandez CS, Loh L, Peut V, Mason RD, Alcantara S, Reece J, Kent SJ. Delivery of immunotherapy with peptide-pulsed blood in macaques. Virology 2008; 378: 201-204.

De Rose R, Fernandez CS, Smith MZ, Batten CJ, Alcantara S, Peut V, Rollman E, Loh L, Mason RD, Wilson K, Law MG, Handley AJ, Kent SJ. Control of Viremia and Prevention of AIDS following Immunotherapy of SIV-Infected Macaques with Peptide-Pulsed Blood. PloS Pathogens, 2008; 4(5): e1000055. doi:10.1371/journal.ppat.1000055.

Loh L, Kent SJ. Quantification of Simian Immunodeficiency Virus Cytotoxic T Lymhocyte Escape Mutant Viruses. AIDS Research and Human Retroviruses, 2008; 24 (8): 1067-1072.

Petravic J, Loh L, Kent SJ, Davenport MP. CD4+ Target cell availability determines the dynamics of immune escape and reversion in vivo. J Virol, 2008; 82: 4091-4101.

Kent SJ, De Rose R, Mokhonov VV, Mokhonova EI, Fernandez CS, Alcantara S, Rollman E, Mason RD, Loh L, Peut V, Reece JC, Wang XJ, Wilson KM, Suhrbier A, Khromykh A. Evaluation of recombinant Kunjin replicon SIV vaccines for protective efficacy in macaques. Virology, 2008; 374: 528-534.

Loh L, Petravic J, Batten CJ, Davenport MP, Kent SJ. Vaccination and timing influence SIV immune escape viral dynamics in vivo. PloS Pathogens, 2008; 4(1): e12 doi:10.1371/journal.ppat.0040012.

Examples of research involving marmosets:

Collins MG, Rogers NM, Jesudason S, Kireta S, Brealey J, Coates PT. Spontaneous glomerular mesangial lesions common marmoset monkeys Callithrix jacchus benign non-progressive glomerulopathy. Journal of Medical Primatology. Dec 2014, Vol. 43 Issue 6, p477.

Chaplin TA, Yu HH, Soares JG, Gattass R, Rosa MG. A conserved pattern of differential expansion of cortical areas in simian primates. J Neurosci. 2013 Sep 18;33(38):15120-5.

Rajan, R., Dubaj, V., Reser, D.H., Rosa, M.G., 2013, Auditory cortex of the marmoset monkey - complex responses to tones and vocalizations under opiate anaesthesia in core and belt areas, European Journal Of Neuroscience [P], vol 37, issue 6, Wiley-Blackwell Publishing Ltd, UK, pp. 924-941.

Burman KJ, Bakola S, Richardson KE, Reser DH, Rosa MG. Patterns of cortical input to the primary motor area in the marmoset monkey. J Comp Neurol. 2013 Aug 12. doi: 10.1002/cne.23447.

Yu HH, Chaplin TA, Egan GW, Reser DH, Worthy KH, Rosa MG. Visually evoked responses in extrastriate area MT after lesions of striate cortex in early life. J Neurosci. 2013 Jul 24;33(30):12479-89.

Lui LL, Bourne JA, Rosa MG. Relationship between size summation properties, contrast sensitivity and response latency in the dorsomedial and middle temporal areas of the primate extrastriate cortex. PLoS One. 2013 Jun 28;8(6):e68276. doi:10.1371/journal.pone.0068276.

Mitra PP, Rosa MG, Karten HJ. Panoptic neuroanatomy: digital microscopy of whole brains and brain-wide circuit mapping. Brain Behav Evol. 2013;81(4):203-5.

Schira MM, Tyler CW, Rosa MG. Brain mapping: the (un)folding of striate cortex. Curr Biol. 2012 Dec 18;22(24):R1051-3.

Rosa MG, Angelucci A, Jeffs J, Pettigrew JD. The case for a dorsomedial area in the primate 'third-tier' visual cortex. Proc Biol Sci. 2013 Jan 7;280(1750):20121372; discussion 20121994. doi: 10.1098/rspb.2012.1372.

Chaplin TA, Yu HH, Rosa MG. Representation of the visual field in the primary visual area of the marmoset monkey: magnification factors, point-image size, and proportionality to retinal ganglion cell density. J Comp Neurol. 2013 Apr 1;521(5):1001-19.

Reser DH, Burman KJ, Yu HH, Chaplin TA, Richardson KE, Worthy KH, Rosa MG. Contrasting patterns of cortical input to architectural subdivisions of the area 8 complex: a retrograde tracing study in marmoset monkeys. Cereb Cortex. 2013 Aug;23(8):1901-22.

Yu HH, Chaplin TA, Davies AJ, Verma R, Rosa MG. A specialized area in limbic cortex for fast analysis of peripheral vision. Curr Biol. 2012 Jul 24;22(14):1351-7.

Dyer AG, Boyd-Gerny S, McLoughlin S, Rosa MG, Simonov V, Wong BB. Parallel evolution of angiosperm colour signals: common evolutionary pressures linked to hymenopteran vision. Proc Biol Sci. 2012 Sep 7;279(1742):3606-15. doi:10.1098/rspb.2012.0827.

Lui LL, Dobiecki AE, Bourne JA, Rosa MG. Breaking camouflage: responses of neurons in the middle temporal area to stimuli defined by coherent motion. Eur J Neurosci. 2012 Jul;36(1):2063-76. 

Burman KJ, Reser DH, Richardson KE, Gaulke H, Worthy KH, Rosa MG. Subcortical projections to the frontal pole in the marmoset monkey. European Journal of Neuroscience 34(2):303-19 (2011).

Passarelli L, Rosa MG, Gamberini M, Bakola S, Burman KJ, Fattori P, Galletti C, 2011, Cortical connections of area V6Av in the macaque: a visual-input node to the eye/hand coordination system. J Neurosci 31(5):1790-801.

Yu HH, Rosa MG, 2010, A simple method for creating wide-field visual stimulus for electrophysiology: mapping and analyzing receptive fields using a hemispheric display.  J Vis 10(14):15.

Burman KJ, Reser DH, Yu HH, Rosa MG, 2010, Cortical Input to the Frontal Pole of the Marmoset Monkey. Cereb Cortex. 2010 Dec 7.

Cloherty SL, Mustari MJ, Rosa MG, Ibbotson MR, 2010, Effects of saccades on visual processing in primate MSTd. Vision Res 50(24):2683-91

Yu HH, Verma R, Yang Y, Tibballs HA, Lui LL, Reser DH, Rosa MG, 2010, Spatial and temporal frequency tuning in striate cortex: functional uniformity and specializations related to receptive field eccentricity. Eur J Neurosci 31(6):1043-62.

Reser DH, Burman KJ, Richardson KE, Spitzer MW, Rosa MG, 2009, Connections of the marmoset rostrotemporal auditory area: express pathways for analysis of affective content in hearing. Eur J Neurosci 30(4):578-92.  

Rosa MG, Palmer SM, Gamberini M, Burman KJ, Yu HH, Reser DH, Bourne JA, Tweedale R, Galletti C, 2009, Connections of the dorsomedial visual area: pathways for early integration of dorsal and ventral streams in extrastriate cortex. J Neurosci 29(14):4548-63.

Burman KJ, Rosa MG, 2009, Architectural subdivisions of medial and orbital frontal cortices in the marmoset monkey (Callithrix jacchus). J Comp Neurol 514(1):11-29.

Burman KJ, Palmer SM, Gamberini M, Spitzer MW, Rosa MGP, 2008, x. J Comp Neurol 506: 860-876.

Padberg J, Franca JG, Cooke DF, Soares JG, Rosa MGP, Fiorani M Jr, Gattass R, Krubitzer L, 2007, Parallel evolution of cortical areas involved in skilled hand use. J Neurosci 27: 10106-10115.

Lui LL, Bourne JA, Rosa MGP, 2007, Spatial and temporal frequency selectivity of neurones in the middle temporal visual area of New World monkeys (Callithrix jacchus). Eur J Neurosci 25: 1780-1792.

Burman KJ, Lui LL, Rosa MGP, Bourne JA, 2007, Development of non-phosphorylated neurofilament expression in neurones of the New World monkey dorsolateral frontal cortex. Eur J Neurosci 25: 1767-1779.

Lui LL, Bourne JA, Rosa MGP, 2007, Spatial summation, end inhibition and side inhibition in the middle temporal visual area (MT). J Neurophysiol 97: 1135-1148.

Bourne JA, Warner CE, Upton DJ, Rosa MGP, 2007, Chemoarchitecture of the middle temporal visual area in the marmoset monkey (Callithrix jacchus): Laminar distribution of calcium-binding proteins (calbindin, parvalbumin) and nonphosphorylated neurofilament. J Comp Neurol 500: 832-849.

Palmer SM, Rosa MGP, 2006, A distinct anatomical network of cortical areas for analysis of motion in far peripheral vision. Eur J Neurosci 24: 2389-2405.

Elston GN, Rosa MGP, 2006, Ipsilateral corticocortical projections to the primary and middle temporal visual areas of the primate cerebral cortex: area-specific variations in the morphology of connectionally identified pyramidal cells. Eur J Neurosci 23: 3337-3345.

Palmer SM, Rosa MGP, 2006, Quantitative analysis of the corticocortical projections to the middle temporal area in the marmoset monkey: evolutionary and functional implications. Cereb Cortex 16: 1361-1375.

Burman KJ, Palmer SM, Gamberini M, Rosa MGP, 2006, Cytoarchitectonic subdivisions of the dorsolateral frontal cortex of the marmoset monkey (Callithrix jacchus), and their projections to dorsal visual areas. J Comp Neurol 495: 149-172.

Bourne JA, Rosa MGP, 2006, Hierarchical development of the primate visual cortex, as revealed by neurofilament immunoreactivity: early maturation of the middle temporal area (MT). Cereb Cortex 16: 405-414.

Lui L, Bourne JA, Rosa MGP, 2006, Functional response properties of neurons in the dorsomedial visual area of New World monkeys (Callithrix jacchus). Cereb Cortex 16: 162-177.

Rosa MGP, Manger PR, 2005, Clarifying homologies in the mammalian cerebral cortex: The case of the third visual area (V3). Clin Exp Pharmacol Physiol 32: 327-339.

Rosa MGP, Tweedale R, 2005, Brain maps, great and small: lessons from comparative studies of primate visual cortical organization. Phil Trans R Soc Lond B 360: 665-691.

Lui LL, Bourne JA, Rosa MGP, 2005, Single-unit responses to kinetic stimuli in New World monkey area V2: Physiological characteristics of cue-invariant neurones. Exp Brain Res 162: 100-108.

Bourne JA, Warner CE, Rosa MGP, 2005, Topographic and laminar maturation of striate cortex in early postnatal marmoset monkeys, as revealed by neurofilament immunohistochemistry. Cereb Cortex 15: 740-748.

Rosa MGP, Palmer SM, Gamberini M, Tweedale R, Piñon MC, Bourne JA, 2005, Resolving the organization of the New World monkey third visual complex: The dorsal extrastriate cortex of the marmoset (Callithrix jacchus). J Comp Neurol 483: 164-191.

Manger PR, Rosa MGP, 2005, Visual thalamocortical projections in the flying fox: Parallel pathways to striate and extrastriate areas. Neuroscience 130: 497-511.

Bourne JA, Lui L, Tweedale R, Rosa MGP, 2004, First- and second-order stimulus length selectivity in New World monkey striate cortex. Eur J Neurosci 19: 169-180.

Bourne JA, Rosa MGP, 2003, Preparation for the in vivo recording of neuronal responses in the visual cortex of anaesthetised marmosets (Callithrix jacchus). Brain Res Brain Res Protoc 11: 168-177.

Bourne JA, Rosa MGP, 2003, Neurofilament protein expression in the geniculostriate pathway of a New World monkey (Callithrix jacchus), Exp Brain Res 150:19-24.

Bourne JA, Rosa MGP, 2003, Laminar expression of neurofilament protein in the superior colliculus of the marmoset monkey (Callithrix jacchus). Brain Res 973: 142-145.

Bourne JA, Tweedale R, Rosa MGP, 2002, Physiological responses of New World monkey V1 neurons to stimuli defined by coherent motion. Cereb Cortex 12: 1132-1145.

Rosa MGP, 2002, Visual maps in the adult primate cerebral cortex: some implications for brain development and evolution. Braz J Med Biol Res 35: 1485-1498.

Examples of research involving baboons:

Keane, F., Farrell, P., Vieira de Ribeiro, A., Osborne, B., Yu, D., Seth, D., Rahman, K., Haber, P., Topaloglu, A., Wang, C., Thomson, S., Yao, T., Hennessy, A., Prins, J., Twigg, S., McLennan, S., McCaughan, G., Bachovchin, W., Gorrell, M., Seelk, S., Gall, M., Chowdhury, S., Poplawski, S., Lai, J., Li, Y. and Wu, W. (2014), 'Quantitation of fibroblast activation protein (FAP)-specific protease activity in mouse, baboon and human fluids and organs', FEBS Open Bio, vol 4 , pp 43 - 54.

Yeung, K., Lind, J., Heffernan, S., Sunderland, N., Hennessy, A. and Makris, A. (2014), 'Comparison of indirect and direct blood pressure measurements in baboons during ketamine anaesthesia', Journal of Medical Primatology.

Dennis, A., Castro, J., Heffernan, S. and Hennessy, A. (2012), 'Haemodynamics using transthoracic echocardiography in healthy pregnant and non-pregnant baboons (Papio hamadryas)', Journal of Medical Primatology, vol 41, no 2 , pp 122 - 129.

Sunderland, N., Hennessy, A., Thomson, S., Heffernan, S., Lim, S., Thompson, J., Ogle, R., McKenzie, P., Kirwan, P. and Makris, A. (2011), 'Tumor necrosis factor alpha induces a model of preeclampsia in pregnant baboons (Papio hamadryas)', Cytokine, vol 56, no 2 , pp 192 - 199.

Balasuriya, H., Bell, P., Waugh, R., Thompson, J., Gillian, A., Hennessy, A. and Makris, A. (2010), 'Primate maternal placental angiography', Placenta, vol 31, no 1 , pp 32 - 36.

Thomson, S., Mclennan, S., Hennessy, A., Broughton, P., Bonner, J., Zoellner, H., Yue, D. and Twigg, S. (2010), 'A novel primate model of delayed wound healing in diabetes : dysregulation of connective tissue growth factor', Diabetologia, vol 53, no 3 , pp 572 - 583.

Graves, L., Hennessy, A., Sunderland, N., Heffernan, S. and Thompson, S. (2009), 'Incidence of lymphoma in a captive-bred colony of Hamadryas Baboons (Papio Hamadryas)', Australian Veterinary Journal, vol 87, no 6 , pp 238 - 243.

Ilsar, R., Chawantanpipat, C., Chan, K., Waugh, R., Hennessy, A., Celermajer, D. and Ng, M. (2009), 'Measurement of pulmonary flow reserve in higher primates', Clinical and Experimental Pharmacology and Physiology, vol 36, no 8 , pp 797 - 802.

Sunderland, N., Heffernan, S., Thomson, S. and Hennessy, A. (2008), 'Maternal parity affects neonatal survival rate in a colony of captive bred baboons (Papio hamadryas)', Journal of Medical Primatology, vol 37, no 5 , pp 223 - 228.

Thomson, S., Mclennan, S., Kirwan, P., Heffernan, S., Hennessy, A. and Yue, D. (2008), 'Renal connective tissue growth factor correlates with glomerular basement membrane thickness and prospective albuminuria in a non-human primate model of diabetes: possible predictive marker for incipient diabetic nephropathy', Journal of Diabetes and its Complications, vol 22, no 4 , pp 284 - 294.

Orange, S., Hennessy, A., Thompson, J., Rasko, J., Vaughan, J., Olive, E., Pedler, M. and Horvath, J. (2005), 'Interleukin-10 Regulates Arterial Pressure In Early Primate Pregnancy', Cytokine, vol 29, no 4 , pp 176 - 185.