Further experiments from Bionics Institute that require kittens to be deafened on their first day of life

George, S, Wise, A, Fallon, J & Shepherd, R 2015, 'Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats ', Journal Of Neural Engineering, 12, 3.


Associated Institution(s): Royal Victorian Eye and Ear Hospital, the Bionics Institute, and The University of Melbourne

The Experiment

The experiment from 2015 aimed to test four different cochlea implant stimulation methods on kittens with artificially induced chronic deafness. They aimed to discover which provides the highest clarity with the lowest electrical current, as well as the effect of different positions of the implant on its performance.

Six kittens underwent an experimental deafness procedure, which involved daily injections of neomycin sulphate, an antibiotic that has hearing loss side effects. These injections commenced the day after birth and continued for 20 days. Injections were continued if necessary until the kittens registered as profoundly deaf. Kittens were deaf for a period of 10-12 months before the experiment commenced.

The experiment was conducted over 2-3 days where the cats were anaesthetised, intubated, and kept unconscious throughout. The cochlea implants were surgically inserted after which the cats were placed in a restrictive metal frame called a stereotaxic frame, which positions their head with metal rods in the ears and a metal clamp on the nose.

A craniotomy, which is invasive brain surgery, was performed on the cats where a segment of their skill was removed followed by removal of the cerebral cortex, so that the section of brain associated with auditory processing could be exposed.

Different currents were then used to stimulate the electrodes in the implants to determine the effectiveness and clarity of the different models. Brain activity of the auditory processing region was also monitored through a silicon-recording device that was implanted during the craniotomy.

After data was collected for the cochlea implants, the cats were killed and the implants removed for analysis.

Background

The Bionics Institute, in conjunction with The University of Melbourne, is continuing to conduct invasive cochlea experiments involving the deafening of cats. The facility has conducted numerous studies in the past 10 years that have comparable methods which all involve the deafening and killing of the cat subjects. The following is a non-exhaustive summary of some of the other research involving cats used in studies on human hearing, and what the cats were subjected to. The institute also has been known to perform similar research on guinea pigs, and other research on cats used in studies on the human eye.

Reference – Bionics Institute

Year

Animal use

Coco, A, Epp, S, Fallon, J, Xu, J, Millard, R, & Shepherd, R 2007, 'Research paper: Does cochlear implantation and electrical stimulation affect residual hair cells and spiral ganglion neurons?', Hearing Research, 225, pp. 60-70

 

2007

8 kittens deafened at 14 days of age and killed at completion of experiment

Fallon, J, Irvine, D, & Shepherd, R 2009, 'Cochlear implant use following neonatal deafness influences the cochleotopic organization of the primary auditory cortex in cats', The Journal Of Comparative Neurology, 512, 1, pp. 101-114

 

2009

17 kittens deafened the day after birth, then killed after completion of experiment

 

Wise, A, Fallon, J, Neil, A, Pettingill, L, Geaney, M, Skinner, S, & Shepherd, R 2011, 'Combining cell-based therapies and neural prostheses to promote neural survival', Neurotherapeutics: The Journal Of The American Society For Experimental Neurotherapeutics, 8, 4, pp. 774-787

2011

17 cats deafened and total of 24 cats killed at the conclusion of the experiment

George S S, Wise A K, Shivdasani M N, Shepherd R K and Fallon J B, 2014, ‘Evaluation of focused multipolar stimulation for cochlear implants in acutely deafened cats’ Journal of Neural Engineering, 11 065003

 

2014

6 cats were deafened and then killed after completion of experiment

Irving, S, Wise, A, Millard, R, Shepherd, R, & Fallon, J 2014, 'A partial hearing animal model for chronic electro-acoustic stimulation', Journal Of Neural Engineering, 11, 4, p. 046008

2014

21 kittens were deafened at 5 days of age, 10 other kittens were deafened at 7 moths. All 31 cats were killed at the end of the experiment.

Fallon, J, Shepherd, R, Nayagam, D, Wise, A, Heffer, L, Landry, T, & Irvine, D 2014, 'Effects of deafness and cochlear implant use on temporal response characteristics in cat primary auditory cortex', Hearing Research, 315, pp. 1-9

2014

15 kittens were deafened one day after birth, 2 others at a later date. A total of 17 cats killed at the completion of the experiment

Fallon, J, Shepherd, R, & Irvine, D 2014, 'Effects of chronic cochlear electrical stimulation after an extended period of profound deafness on primary auditory cortex organization in cats', The European Journal Of Neuroscience, 39, 5, pp. 811-820

2014

10 kittens were deafened one day after birth. All cats were killed at the completion of the experiment

George, S, Shivdasani, M, Wise, A, Shepherd, R, & Fallon, J 2015, 'Electrophysiological channel interactions using focused multipolar stimulation for cochlear implants', Journal Of Neural Engineering, 12, 6, p. 066005

2015

7 cats were deafened and a total of 8 cats were killed after completion of experiment

Featured experiment: George, S, Wise, A, Fallon, J, & Shepherd, R 2015, 'Evaluation of focused multipolar stimulation for cochlear implants in long-term deafened cats', Journal Of Neural Engineering, 12, 3, p. 036003

2015

6 kittens were deafened from one day after birth. All cats were killed after the completion of the experiment

Fallon, J, Irving, S, Pannu, S, Tooker, A, Wise, A, Shepherd, R, & Irvine, D 2016, 'Second spatial derivative analysis of cortical surface potentials recorded in cat primary auditory cortex using thin film surface arrays: comparisons with multi-unit data', Journal Of Neuroscience Methods, Apr. 5, 2016. ISSN: 0165-0270.

2016

13 cats were deafened, 14 cats were killed after completion of experiment


As well as the question of the research being relevant to human medicine, the sheer number of cats subjected to these invasive experimental procedures from one day of age is quite shocking, and only seems to be increasing over the years. With such similar experiments being conducted each year, the institute appears to be abusing their use of cats in a wasteful manner. With such similar experimental methods in place for all the studies there is the question of what new information is being obtained with each new experiment that could not be deduced from any of the previous studies? Continually and persistently deafening and killing cats and receiving large amounts of tax-payer funding to do so is something that needs to be addressed.

Typical grants from the NHMRC for these types of studies are in the hundreds of thousands. Here are just a few grants that have been awarded to researchers of the Bionics Institute over the past few years to conduct their cochlea experiments:

  • Professor Rob Shepherd received $437,213.00 for research over 2009-2012 on cochlear implants

  • Professor James Fallon received $560,267.00 for research over 2011-2014 on cochlear implants

  • Professor Rob Shepherd received $506,725.00 for research over 2011-2013 on auditory nerves and deafness.

  • Professor James Fallon received $958,739.00 for research over 2015-2018 on bilateral cochlea implants (NHMRC, 2016)


  • Should this much tax payer money be dedicated to research that involves deafening and killing cats?

    Source of funding data: National Health and Medical Research Council (NHMRC), 2016, 'NHMRC Grants 2000-2015', Australian Government, Canberra, viewed 18th April 2016,

    Relevance of Results

    Cats and humans are vastly different species, and these differences extend to the structure and function of the ears. A recent study by Rattay et al. (2013) compared the anatomical auditory nerve differences between the two species in order to determine if results from the cat ear are really transferrable to humans. The study found a number of differences, as expected, and states the following:

    "Shorter total lengths of SGNs in cat, thinner processes, smaller cell bodies and fundamental differences in myelination are obvious reasons not to rely on a cat model when signalling in human auditory nerve is discussed as these differences between the species may lead to important differences in auditory nerve function."[1]

    With the looming question of how relevant research on cats is to humans, should such large amounts of invasive experiments be permitted?

    [1] Rattay, F, Potrusil, T, Wenger, C, Wise, A, Glueckert, R, & Schrott-Fischer, A 2013, 'Impact of Morphometry, Myelinization and Synaptic Current Strength on Spike Conduction in Human and Cat Spiral Ganglion Neurons', Plos ONE, 8, 11, p. 1

    Funding

    The featured experiment was funded by the National Health and Medical Research Council (NHMRC) the Australian Research Council (ARC) ($350,000), and The Garnett Passe and Rodney Williams Memorial Foundation. The Bionics Institute is also supported by the Victorian Government through its Operational Infrastructure Support Program.

    What You Can Do

    Please write to the following to voice your concerns about the number of cats subjected to this research every year, to question the relevance of the research to human medicine and to question the decisions of the Animal Ethics Committee who approved this research::

    The Research and Ethics Office
    The Royal Victorian Eye and Ear Hospital
    Locked Bag 8
    East Melbourne VIC 8002
    Email: ethics@eyeandear.org.au


    Please also write to the following funding bodies to ask why they are funding the use of animals in experimental procedures when these animals do not appropriately model humans, and to voice your concerns about the number of cats subjected to this research every year.

    Professor Anne Kelso
    National Health and Medical Research Council
    GPO Box 1421
    Canberra ACT 2601
    Email: nhmrc@nhmrc.gov.au

    And

    Professor Aidan Byrne
    Australian Research Council
    GPO Box 2702
    Canberra ACT 2601
    Email: ceo@arc.gov.au

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